Brian Marples, Ph.D.
- Research Professor
- Director of Radiobiology Department of Radiation Oncology University of Miami Miller School of Medicine
- Radiation Oncology
Dr. Marples' research focuses on tumor and normal tissue radiobiology, with studies designed to improve tumor eradication by maximizing tumor radiation response while minimizing toxicity of normal tissue. These include cell culture and xenograft studies investigating the pattern of radiation delivery as a mechanism to exploit dose-dependent ATM-mediated DNA damage response pathways to improve the treatment of tumors. Other studies investigate podocyte sphingolipid homeostasis in the normal kidney after irradiation.