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Marples Lab

Radiobiology Research Laboratory

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Investigator / Contact Person Brian Marples

Research Focus

My main research focus is tumor and normal tissue radiobiology, with studies designed to improve tumor eradication by maximizing tumor radiation response while minimizing toxicity of normal tissue. On-going studies include cell culture and xenograft studies investigating the pattern of radiation delivery as a mechanism to exploit dose-dependent ATM-mediated DNA damage response pathways to improve the treatment of glioblastoma. Complementary studies are examining radiation-induced normal tissue sequelae and we have recently shown that kidney irradiation induces loss of sphingomyelin-phosphodiesterase-acid-like expression in cultured podocytes, and alters podocyte sphingolipid homeostasis inducing loss of filopodia. After irradiation, we discovered that the actin-binding protein ezrin relocated from the podocyte plasma membrane to the cytosol, promoting cytoskeletal remodeling. Irradiation triggered a time-dependent loss of SMPDL3b and coincident elevation in ceramide levels

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