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Pillai Lab

Innate Immune Regulation, Transplantation Tolerance, and Immunotherapy

Funding

PI FUNDING

Active:

1R01HL133462-01A1 (NHLBI) (Pillai) 01/01/18 – 12/31/2021 Novel Innate Mechanisms of Immune Tolerance in Allotransplantation Investigates novel myeloid-driven immune tolerance strategies for haplo-identical hematopoietic cell transplantation (HCT) and the role of innate lymphocytes in durable maintenance of tolerance across MHC barriers.

Jack Lombardo Grant, Women’s Cancer Association) (Pillai) 07/01/2017 - 6/30/2018 Targeted NKT Immunotherapy of High-risk Malignancies To develop human iNKT-CAR immunotherapies with optimized targeting and anti-tumor activity.

George E. Batchelor Pediatric Research Foundation (Pillai) 07/01/2016 - 6/30/2021 Innate Immune Tolerance and Immunotherapy To optimize clinical protocols for haploidentical HCT in children with hemoglobinopathies and to establish novel human iNKT and other innate immune populations with optimized targeting and anti-tumor activity for cancer immunotherapy.

Completed:

R56HL125449-01 (NHLBI) (Pillai) 09/01/15 – 01/01/2018
Novel Innate Mechanisms of Immune Tolerance in Allotransplantation for Hemoglobinopathies

R12/94-000 Program Project (Pillai) 11/01/10 – 06/30/2016
Matched Unrelated and Parent-to-Child Human NKT Cell Immunotherapy of Malignancies Role: Sub-P.I. (Component M)

V Scholar Award, V Foundation for Cancer Research (Pillai) 11/01/12–10/31/2014
Augmenting Cytotoxicity of Ex vivo Expanded Human iNKT Cells for Leukemia Immunotherapy

Exploratory Grant (Pillai) 01/01/12 – 06/17/2014
Evan Dunbar Neuroblastoma Foundation
Role of Natural Killer T Cells in Hu14.18K322A Anti-GD2 Antibody Mediated Cytotoxicity

5-P30CA021765-36 (NCI/NIH) (Pillai) 03/01/11–02/28/2013
Ex vivo Expansion of Human iNKT Cells for Immunotherapy of Pediatric Leukemia

Hyundai Foundation Scholar Award (Pillai) 12/01/11 – 06/01/2012
Ex vivo Expansion of Human iNKT cells for Immunotherapy of Pediatric Cancers

K08HL-088260-01 (NHLBI) (Pillai) 12/01/07 – 11/30/2012
Regulatory T Cells, Mixed Chimerism: A Novel Transplant Strategy for Thalassemias

Ruth Kirschstein NRSA 2T32HL007952-11A1 (NHLBI) 09/01/04-08/31/2007
Immunobiology of Innate and Adaptive Regulatory T Cells after Hematopoietic Cell Transplantation

Stanford Firestone Fellowship, Hugh O’Brian Foundation (Pillai) 09/01/88-03/01/1990
A Novel Role for IL-3 in Follicular Lymphoma Proliferation

HHMI/NIH Summer Research Fellowship 06/01/87-09/01/1987

TRAINEE FUNDING:

Lemuel Diggs Endowed Fellowship in Sickle Hemoglobinopathies 05/01/13–08/30/2014
Mechanisms of Specific Immune Tolerance Induction in Allotransplant for Hemoglobinopathies

St. Jude Children’s Academic Programs Office 03/06/12–03/05/2013
Ex vivo Expansion of Human Natural Killer T cells for Adoptive Immunotherapy

Sumara Endowed Fellowship in Cellular and Gene Therapy 01/01/10–12/31/2012
Role of Myeloid Derived Suppressor Cells in Allotransplant Tolerance