Dr. Yang’s laboratory has been focused on investigating the underlying mechanism of hematopoietic malignancies, with a specific focus on the role of ASXL family, BAP1, and NF1 in the pathogenesis of myeloid malignancies. Alteration of ASXL family genes is in multiple forms of myeloid malignancies, including myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), MDS/MPN (such as CMML and JMML), and acute myeloid leukemia (AML). However, the role of ASXL1 in the pathogenesis of myeloid malignancies and normal hematopoiesis remains largely unknown. Mutations in NF1 tumor suppressor gene cause the common genetic disorder neurofibromatosis type 1 (NF1) which is associated with a predisposition to JMML, MDS, and AML. Current research projects of Dr. Yang’s laboratory include 1) to understand the cellular/molecular mechanisms underlying ASXL1/2/3 alteration-mediated myeloid malignancies; 2) to investigate cooperative effects between Asxl1 and Nf1 or JAK2V617F.