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NanoKnife®/IRE Ablation


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NanoKnife® treatment is a type of irreversible electroporation (IRE) ablation that uses electrical currents to destroy (ablate) cancer cells. It can be used to treat many types of cancers that would otherwise be untreatable, such as:

  • Liver cancer
  • Neuroendocrine tumors
  • Pancreatic cancers near blood vessels

This procedure uses no incisions, has minimal scarring, and has a fast recovery time. You may need multiple NanoKnife procedures to treat different tumors. The interventional radiology experts at Sylvester are experienced in performing this procedure and can help determine the best option for you.

Why Choose Us?

Expert care from highly trained interventional radiologists. Our interventional radiologists and radiology specialists are experts in a variety of minimally invasive procedures — everything from treatments to clear blocked blood vessels to advanced cancer therapies like NanoKnife®.

Leading-edge imaging care in South Florida. Our doctors are also researchers discovering new ways to improve diagnosis and treatment. That means you can get some of today’s most promising advancements through clinical trials. You benefit from the latest developments that are fast-tracked from the lab to the bedside.

Questions? We're here to help.

Our appointment specialists are ready to help you find what you need. Contact us today.

Who is a Candidate? 

Your doctor may recommend NanoKnife treatment if your cancer cannot be removed using surgery due to the tumor being too close to an artery or is too hard to reach.

Because the NanoKnife uses electrical currents, you may not be able to undergo this procedure if you have a pacemaker, nerve stimulator, or an arrhythmia. The procedure may negatively affect these devices and conditions.

What to Expect

Your doctor may tell you not to eat or take certain medications, like aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) before your procedure. Always tell your doctor what medicines you are taking, including vitamins or herbs.

For your NanoKnife procedure, you will be sedated or under anesthesia, meaning you will be asleep during the procedure. Your doctor will also apply local anesthetic (numbing at the site of the procedure) to the area being treated so you won’t feel pain.

Once you are sedated, your doctor will use imaging technology, like X-rays, to place needles into the tumor. After the needles are in place, an electrical current runs through the needles, destroying the cancer cells.

Once all cancer cells are destroyed, your doctor then removes the needles and places a bandage or dressing over the injection sites. The entire procedure may take between two and four hours. Depending on the extent of your NanoKnife surgery, you may need to stay in the hospital for just a few days or longer than a week. You should be able to resume all normal activities within a few weeks.

Accepted Insurances

Note: Health plans that are currently contracted with UHealth are listed below. However, please check with your insurance provider to verify that UHealth is part of your provider network.