What is Peripheral Artery Disease (PAD)?
PAD is caused by atherosclerotic disease or plaque buildup inside the blood vessels carrying blood to your legs.
An estimated 8.5 million Americans and more than 200 million people worldwide have PAD. If you have PAD, you are at increased risk of heart attack and stroke. The 5-year death rate among patients diagnosed with PAD may be as high as 33 percent, with most deaths due to heart attack and stroke.
What is Critical Limb Ischemia (CLI)?
CLI is the most severe and deadly form of PAD. CLI is defined as ischemic rest pain, foot/toe ulcers, or gangrene. Approximately 2 million US citizens suffer from CLI. CLI is on the rise due to the rise of diabetes and kidney disease. Patients with CLI have a major amputation rate as high as 40 percent at 6 months and a mortality rate of 20 to 25 percent in the first year after diagnosis. At 5 years, the all-cause mortality rate of 70 percent exceeds that of colorectal cancer, breast cancer, stroke, and coronary artery disease. Oftentimes CLI patients undergo amputation without any type of vascular evaluation by a highly trained vascular interventional physician who has expertise in non surgical treatment techniques.
- High Cholesterol
- High Blood Pressure
- Renal Failure
Who is at risk for PAD?
- Patients under 50 years of age with diabetes mellitus and one or more additional risk factors for atherosclerosis/plaque buildup
- Patients 50 to 64 years of age with one of the risk factors above or family history of PAD
- Patients 65 years of age or older
- Patients with known atherosclerotic disease/plaque buildup in another part of the body including the heart, neck (carotid artery), arms (subclavian artery), abdomen (abdominal aortic aneurysm, renal artery narrowing, or narrowing in arteries of the bowel).
The most common symptom of PAD is leg pain and claudication, which is leg pain that occurs when walking or exercising and disappears at rest.
Other symptoms of PAD/CLI include discoloration, numbness, and tingling in the lower legs and feet, coldness in the lower legs and feet, and ulcers or sores on the legs or feet that don't heal.