Research Focus

Over the last 15 years, using a combination of cell biology, protein biochemistry and mouse genetics my laboratory has established essential functions of glioblastoma drivers (Carro et al. Nature 2010; Singh et al. Science 2012; Frattini et al. Nature Genetics 2013; Lee et al. Nature 2016; Frattini et. al. Nature 2018; D’Angelo et. al. Nature Medicine 2019). Some of the glioblastoma oncogenic pathways are engaged to preserve stemness and induce other cancer hallmarks.