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Ocular Oncology Laboratory

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Investigator / Contact Person Zelia Correa, M.D., Ph.D.


The Ocular Oncology Laboratory is dedicated to research leading directly to better treatments for ocular tumors. Ongoing basic research includes experiments that involve single-cell sequencing, epigenetic deregulation, immune microenvironment, and creation of a syngeneic mouse model for metastatic uveal melanoma. The lab actively translates new findings to the clinic.

The two major research directions in the lab are: (1) continue to use genomic techniques to identify new genetic alterations associated tumor initiation and progression in major forms of eye cancer, and (2) use cell-based and experimental models to understand the biological significance of these genetic alterations.

  • Cellular and Genomic Landscape of Uveal Melanoma at Single Cell Resolution

  • Molecular Predictive Testing in Ocular Melanoma

  • Characterization and targeting of the epigenetic state underlying uveal melanoma liver metastasis

  • Single-Cell Analysis of LAG3 Checkpoint Inhibition in Metastatic Uveal Melanoma

  • Epigenetic Deregulation and Tumor Progression Due to the Loss of a Novel Interaction between HDAC1 and BAP1 in Uveal Melanoma