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Ocular Oncology Laboratory

Ocular Oncology Laboratory

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Investigator / Contact Person Zelia Correa, M.D., Ph.D.
Lab 305-326-6020
Office 305-326-6166
Email zcorrea@med.miami.edu

Research

The Ocular Oncology Laboratory is dedicated to research leading directly to better treatments for ocular tumors. Ongoing basic research includes experiments that involve single-cell sequencing, epigenetic deregulation, immune microenvironment, and creation of a syngeneic mouse model for metastatic uveal melanoma. The lab actively translates new findings to the clinic.

The two major research directions in the lab are: (1) continue to use genomic techniques to identify new genetic alterations associated tumor initiation and progression in major forms of eye cancer, and (2) use cell-based and experimental models to understand the biological significance of these genetic alterations.

  • Cellular and Genomic Landscape of Uveal Melanoma at Single Cell Resolution

    The major goal of this project is to provide the first comprehensive genomic and cellular atlas of uveal melanoma at single cell resolution.

  • Molecular Predictive Testing in Ocular Melanoma

    The major goal of this project is to determine accurate, clinically feasible testing platforms for uveal melanoma. 

  • Characterization and targeting of the epigenetic state underlying uveal melanoma liver metastasis

    The major goal is to elucidate the potential mechanisms that lead to uveal melanoma liver metastasis.

  • Single-Cell Analysis of LAG3 Checkpoint Inhibition in Metastatic Uveal Melanoma

    The major goal of this project is to examine the tumor microenvironment and therapeutic response in uveal melanoma by targeting LAG3 for inhibition which will lead to a paradigm shift in the management of metastatic UM. 

  • Epigenetic Deregulation and Tumor Progression Due to the Loss of a Novel Interaction between HDAC1 and BAP1 in Uveal Melanoma

    The major goal of this project is to characterize the BAP1-HDAC1 interaction and the consequences of its disruption by BAP1 mutations as an avenue to discovering new therapeutic strategies.


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