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Ocular Oncology Laboratory

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Investigator / Contact Person Zelia Correa, M.D., Ph.D.

Research

The Ocular Oncology Laboratory is dedicated to research leading directly to better treatments for ocular tumors. Ongoing basic research includes experiments that involve single-cell sequencing, epigenetic deregulation, immune microenvironment, and creation of a syngeneic mouse model for metastatic uveal melanoma. The lab actively translates new findings to the clinic.

The two major research directions in the lab are: (1) continue to use genomic techniques to identify new genetic alterations associated tumor initiation and progression in major forms of eye cancer, and (2) use cell-based and experimental models to understand the biological significance of these genetic alterations.

  • Cellular and Genomic Landscape of Uveal Melanoma at Single Cell Resolution

  • Molecular Predictive Testing in Ocular Melanoma

  • Characterization and targeting of the epigenetic state underlying uveal melanoma liver metastasis

  • Single-Cell Analysis of LAG3 Checkpoint Inhibition in Metastatic Uveal Melanoma

  • Epigenetic Deregulation and Tumor Progression Due to the Loss of a Novel Interaction between HDAC1 and BAP1 in Uveal Melanoma