Dr. Rai's research program focuses on development of molecular strategies to activate tumor suppressor pathways in cancer cells through modulation of cellular redox status and DNA repair mechanisms. These mechanisms are typically enhanced in aggressive tumors to overcome intrinsic oncogenic stress arising from elevated levels of reactive oxygen species (ROS) that mediate pro-malignant signaling. Dr. Rai's studies have identified novel therapeutic targets for RAS-driven lung cancer and hormone-refractory prostate cancer, which have few current treatment options.