Principal Investigator
Enrollment Status
Clinical Trial ID
Clinical Trial Summary
The purpose of this study is to test the hypothesis that allogeneic Mesenchymal Stem Cells
(MSCs) promote systemic and coronary endothelial repair through rescue of bone marrow
progenitors in type 2 diabetic patients with symptomatic IHD compared to placebo.
Phase
Phase 1/Phase 2
Funding Agency/Sponsor
Other
Disease
Other
Enrollment Eligibility
Inclusion Criteria:
1. Be ≥ 18 years of age (males and females).
2. Provide written informed consent.
3. Have a diagnosis of symptomatic ischemic heart disease (IHD) and an indication for
standard-of-care coronary angiography.
4. Have Diabetes Mellitus (DM) type 2 documented by glycated hemoglobin (HbA1C) > 7%, or
on medical therapy for diabetes.
Exclusion Criteria:
1. Be younger than 18 years of age.
2. Have history of prior myocardial Infarction and revascularization.
3. Have a baseline glomerular filtration rate (GFR) <30 ml/min 1.73m2 estimated using the
Modification of Diet for Renal Disease (MDRD) formula.
4. Have poorly controlled blood glucose levels with hemoglobin A1C > 8.5% in the previous
3 months.
5. Have a history of proliferative retinopathy or severe neuropathy requiring medical
treatment.
6. Have an indication for standard-of-care surgical (including valve surgery, placement
of left-ventricular assist device) or percutaneous intervention for the treatment of
valvular heart disease (including valvuloplasty).
7. Have known hypersensitivity or contraindication to aspirin; both heparin and
bivalirudin; all available P2Y12 inhibitors (clopidogrel, prasugrel, and ticagrelor);
or any zotarolimus, cobalt, chromium, nickel, tungsten, acrylic, or fluoropolymers; or
hypersensitivity to contrast media that cannot be adequately premedicated.
8. Have a hematologic abnormality as evidenced by hematocrit < 25%, white blood cell <
2,500/microliter (uL) or platelet values < 100,000/uL without another explanation (per
investigator discretion).
9. Have liver dysfunction, as evidenced by enzymes (AST and ALT) greater than three times
the upper limit of normal.
10. Have a bleeding diathesis or coagulopathy (INR > 1.3), cannot be withdrawn from
anticoagulation therapy, or will refuse blood transfusions.
11. Be an organ transplant recipient or have a history of organ or cell transplant
rejection.
12. Have a clinical history of malignancy within the past 5 years (i.e., subjects with
prior malignancy must be disease free for 5 years), except curatively-treated basal
cell or squamous cell carcinoma, or cervical carcinoma.
13. Have a condition that limits lifespan to < 1 year.
14. Have a history of drug or alcohol abuse within the past 24 months.
15. Be serum positive for HIV, hepatitis B surface antigen (sAg), or viremic hepatitis C.
16. Be currently participating (or participated within the previous 30 days) in an
investigational therapeutic or device trial.
17. Be pregnant, nursing, or of childbearing potential and not on contraceptive
medications. (May participate if on 2 forms of contraceptives).
18. Any other condition that in the judgment of the Investigator would be a
contraindication to enrollment or follow-up.
19. Coronary lesions with restenosis or heavy calcification.