Principal Investigator
Enrollment Status
Clinical Trial ID
Clinical Trial Summary
This phase II trial investigates how well biomarkers on PET/CT imaging drive early
discontinuation of anti-PD-1 therapy in patients with stage IIIB-IV melanoma that cannot be
removed by surgery (unresectable). Anti-PD-1 therapy has become a standard therapy option for
patients with unresectable melanoma. This trial is being done to determine if doctors can
safely shorten the use of standard of care anti-PD1 therapy for melanoma by using biomarkers
seen on PET/CT imaging and tumor biopsy.
Phase
Phase 2
Funding Agency/Sponsor
National Cooperative Group
Disease
Cutaneous Malignancies
Enrollment Eligibility
Inclusion Criteria:
- STEP 0 PRE-REGISTRATION INCLUSION CRITERIA
- Patient must have active advanced melanoma, defined as unresectable stage IIIB-IV by
American Joint Committee on Cancer (AJCC) 8th edition
- Patient must have melanoma originating from cutaneous, acral-lentiginous, or mucosal
primary sites. Patients with melanoma of unknown primary site are eligible. Patients
must not have melanoma from an ocular primary site
- Patient must have had measurable disease by immune related Response Evaluation
Criteria in Solid Tumors (imRECIST) prior to start of initial anti-PD-1 therapy
- Patient must be actively receiving standard of care anti-PD-1 therapy, currently be 52
weeks (+/- 2 weeks) from start of anti-PD-1 therapy, and have not experienced a
toxicity that prevents them from continuing on therapy. Permitted systemic anti-PD-1
therapy regimens include:
- Nivolumab 240 mg IV every (Q)2weeks or 480 mg IV Q4weeks
- Pembrolizumab 200 mg IV Q3weeks or 400 mg IV Q6weeks
- Nivolumab 1 mg/kg plus ipilimumab 3 mg/kg IV Q3weeks induction x 4 doses,
followed by nivolumab 240 mg IV Q2weeks or 480 mg IV Q4weeks maintenance
- Nivolumab 3 mg/kg plus Ipilimumab 1 mg/kg IV Q3weeks induction x 4 doses,
followed by nivolumab 240 mg IV Q2weeks or 480 mg IV Q4weeks maintenance
- Pembrolizumab 2 mg/kg (or 200 mg flat dose) plus Ipilimumab 1 mg/kg IV Q3weeks
induction x 4 doses, followed by pembrolizumab 200 mg IV Q3weeks or 400 mg IV
Q6weeks maintenance
- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0-2
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral
therapy with undetectable viral load within 6 months are eligible for this trial.
Patients with detectable viral loads are excluded as it is unclear if these patients
have a low risk of melanoma progression off anti-PD-1 treatment
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral
load must be undetectable on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated
and cured. For patients with HCV infection who are currently on treatment, they are
eligible if they have an undetectable HCV viral load
- Patients with a prior or concurrent malignancy whose natural history or treatment does
not have the potential to interfere with the safety or efficacy assessment of the
investigational regimen are eligible for this trial
- Patients with known history or current symptoms of cardiac disease, or history of
treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac
function using the New York Heart Association Functional Classification. To be
eligible for this trial, patients should be class 2B or better
- Patient must have experienced complete response, partial response, or stable disease
on restaging CT scans by imRECIST that is maintained on restaging scans obtained at
week 52 (+/- 2 weeks) from start of initial anti-PD-1 therapy
- Patient must have completed an FDG-PET/CT scan at week 52 (+/- 2 weeks) from start of
initial anti-PD-1 therapy
- Patients with PET/CT positive for hypermetabolic lesions: If a core needle, punch
or excisional biopsy and pathological review of a representative lesion was not
performed prior to pre-registration (Step 0) must either:
- Be amenable to undergo a biopsy. Patient must not be on anticoagulation
therapy or, if on anti-coagulation therapy, patient must be able to hold
treatment for a biopsy procedure (core needle, punch or excisional biopsy).
Anti-coagulation therapy is defined as low molecular weight heparin,
warfarin, factor Xa inhibitor, or direct thrombin inhibitor
- Have documentation of inability to perform the biopsy due to feasibility or
safety concerns
- Leukocytes >= 3,000/mcL (obtained =< 4 weeks prior to protocol registration)
- Absolute neutrophil count >= 1,500/mcL (obtained =< 4 weeks prior to protocol
registration)
- Platelets >= 100,000/mcL (obtained =< 4 weeks prior to protocol registration)
- Total bilirubin =< institutional upper limit of normal (ULN) (patients with history of
Gilbert's syndrome are permitted to have a total bilirubin > 1.5 x institutional ULN)
(obtained =< 4 weeks prior to protocol registration)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
=< 2.5 x institutional ULN (obtained =< 4 weeks prior to protocol registration)
- Creatinine =< 1.5 x institutional ULN (obtained =< 4 weeks prior to protocol
registration)
- STEP 1 REGISTRATION INCLUSION CRITERIA
- Patient met all eligibility criteria outlined above
- Patient must register to Step 1 within 4 weeks of registration to Step 0
- Patients must meet one of the following criteria:
- Patient had no positive hypermetabolic lesions on the week 52 FDG-PET/CT.
- Patients with positive hypermetabolic lesion(s) on the week 52 FDG-PET/CT
(positive hypermetabolic = standard uptake volume [SUV] > pooled mediastinal
blood), one of the following must have occurred:
- A representative lesion was biopsied (core needle, punch or excisional
biopsy) within 14 days of registration to Step 0 and subsequent pathology
review performed to determine the presence or absence of viable tumor
- Documentation is present that the patient is not able to undergo biopsy of a
hypermetabolic lesion due to feasibility or safety concerns, i.e., the
lesion location that is not amenable to biopsy
Exclusion Criteria:
- STEP 0 PRE-REGISTRATION EXCLUSION CRITERIA
- Patient must not be receiving concurrent anti-tumor therapies in addition to the
standard of care anti-PD-1 regimens. Patients who are receiving bisphosphonates and
RANKL inhibitors for management of bone metastases are eligible
- Patient must not have brain metastases
- Women must not be pregnant or breast-feeding due to potential harm to an unborn fetus
and possible risk for adverse events in nursing infants with the anti-PD-1 regimens
being used. All females of childbearing potential must have a blood test or urine
study within 14 days prior to registration to rule out pregnancy. A female of
childbearing potential is defined as any woman, regardless of sexual orientation or
whether they have undergone tubal ligation, who meets the following criteria: 1) has
achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral
oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer
therapy does not rule out childbearing potential) for at least 24 consecutive months
(i.e., has had menses at any time in the preceding 24 consecutive months)
- Women of childbearing potential and sexually active males must not conceive or father
children by using accepted and effective method(s) of contraception or by abstaining
from sexual intercourse from the time of study registration and continuing until at
least 5 months after the last dose of anti-PD-1 treatment for female patients and for
at least 7 months after the last dose of anti-PD-1 treatment for male patients who are
sexually active with a women of childbearing potential (WOCBP)