Principal Investigator
Enrollment Status
Clinical Trial ID
Clinical Trial Summary
The purpose of this research is to evaluate how to manage the axillary lymph nodes in
patients with breast cancer. The investigators will determine if a sampling of the lymph
nodes under the arm will give the information necessary to determine if fewer lymph nodes can
be removed.
Phase
N/A
Funding Agency/Sponsor
Institutional
Disease
Breast Cancer
Enrollment Eligibility
Inclusion Criteria:
- Women or men greater than or equal to 18 years.
- Histologically confirmed invasive adenocarcinoma of the breast.
- Clinical T0-4 N2-3 M0 at diagnosis (American Joint Committee on Cancer, 7th Edition)
- Assessment for cN2 disease will be performed by clinical exam and imaging.
Patients should have pathologic level 1 and/or 2 axillary lymph nodes which are
fixed/matted on physical exam.
- Cross-sectional imaging will be used to identify advanced nodal disease involving
the axilla, infraclavicular, supraclavicular, and internal mammary regions, cN3
disease.
- Patients must have biopsy proven involvement of the axillary lymph nodes.
- Receipt of standard multiagent chemotherapy +/- targeted therapy based on tumor
subtype.
- Candidate for surgical management of breast cancer.
- Ability to understand and willingness to sign a written informed consent document.
Exclusion Criteria:
- History of allergic reactions or hypersensitivity to radioactive lymph node mapping
agents or blue dye.
- Pregnancy.