Julio C. Barredo, M.D.
- Associate Chair for Basic Research, Holtz Children's Hospital - Direct
Understanding the survival responses of leukemia cells to energy and metabolic stress-regulated by AMPK. Investigating the role of AMPK in gene regulation via epigenetic mechanisms in leukemia cells under energy/metabolic stress. Exploiting the vulnerabilities of acute leukemia cells, mainly ALL, to translate their laboratory findings into novel clinical trials for ALL by targeting survival pathways elicited by energy or metabolic stress in acute leukemia.