Stephan C. Schürer, Ph.D.
- Interim Director, Drug Discovery, Center for Computational Science
- Molecular and Cellular Pharmacology
Dr. Schürer's research interest in cancer is the identification and development of small molecule compounds with targeted polypharmacology profiles to improve efficacy, reduce resistance, and thus improve clinical duration; while avoiding off-target liabilities. Dr. Schürer's group uses advanced computational methods such as machine learning based on very large datasets, molecular mechanics simulations and various other virtual screening methods to predict likely targets of small molecules. A recent proof of concept study they successfully identified the first dual EGFR kinase and BRD4 BET inhibitor (http://med.miami.edu/news/sylvester-researchers-use-powerful-screening-tools-to-identify-new-cancer-i).