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  • Antihistamines

    If your body is currently reacting to penicillin but your reaction is not life-threatening, your doctor may prescribe an antihistamine or recommend an over-the-counter antihistamine (Benadryl) that can block immune system chemicals that are activated during an allergic reaction.

  • Corticosteroids

    In the case of more serious reactions, your doctor may recommend oral (by mouth) or injected corticosteroids to treat inflammation associated with penicillin allergy.

  • Drug desensitization

    If you need to take penicillin or a penicillin-containing medication and no alternatives are available, your doctor may recommend you undergo drug desensitization under their close supervision. This involves taking a very small dose of penicillin, and then progressively larger doses every 15 to 30 minutes over the course of several hours or a few days. If you reach the desired dose with no reaction, you can continue the treatment with penicillin.