Dr. Lee’s laboratory studies mechanisms involved in the cellular adaptation to the adverse environmental conditions commonly found within the tumor microenvironment (hypoxia and extracellular acidosis). These extracellular stimuli alter fundamental cellular pathways by:
1. Activating an alternate translation apparatus that synthesizes proteins only in the absence of oxygen and
2. Inducing a new class of long noncoding RNAs that regulate protein function. Ongoing projects blend basic and translational scientific research from the identification of novel stress-induced long noncoding RNA to discovery of drug as small molecular inhibitors for these essential tumor biology pathways.