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Xu Lab

Taxmen chemotherapy and resistance

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Investigator / Contact Person Xiangxi Xu, Ph.D.

Research

The lab is interested in ovarian cancer biology and therapies, embryonic stem cells, and early embryogenesis. Currently several key projects are planned in the lab:

  • We study the roles of AMH (Anti-Mullerian Hormone) in regulation of progenitor cells in ovarian cancer development, pathology in menopause, and the influences on sex-biased biology.
  • We investigate the mechanisms of Taxol in stabilizing microtubules and killing of cancer cells, and mechanisms and strategies to overcome drug resistance.
  • Based on a recent lab finding, we are developing application of low intensity ultrasound to impact microtubules as a strategy in countering side efforts in cancer chemotherapy, namely myelosuppression, peripheral neuropathy, and alopecia.