Dr Sekeres has focused on myeloid malignancies, and particularly myelodysplastic syndromes and acute myeloid leukemia in older adults, for his entire career. He has developed innovative therapies for myeloid malignancies; helped define the molecular biology of myeloid neoplasms along with clinical correlates; helped redefine prognostication, including innovative methods using machine learning and artificial intelligence; and helped define the epidemiology and patient reported outcomes in these conditions.

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