Don Soffer Clinical Research Center 410Q
Nipun B. Merchant, M.D.
- Associate Director of Translational Research
- Chief Surgical Officer
- Vice Chair of Surgical Oncology Services
- Director of Surgical Oncology Research
Dr. Merchant investigates how alterations in RAS and STAT3 signaling pathways affect the tumor stroma and immune microenvironment in pancreatic cancer. Using genetically engineered mouse models and 3-dimensional in vitro models, Dr. Merchant's lab studies how cross-talk between these pathways in the tumor and stroma affect epithelial-to-mesenchymal transition, changes in the tumor microenvironment and alterations in immune response to enhance therapeutic efficacy in pancreatic cancer.