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Figueroa Lab

Epigenetic Regulation of Hematopoiesis

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Investigator / Contact Person Maria Figueroa

Research Focus

The Figueroa lab studies the role of epigenetic modifications in transcriptional regulation during normal and malignant hemopoiesis. Our focus is mainly on how changes in normal DNA methylation and hydroxymethylation patterns occur during malignant transformation and how these changes may contribute to the leukemogenic process. We use a combination of computational approaches based on genome-wide next generation sequencing data as well as in vitro and in vivo modeling to determine the consequences of the epigenetic lesions that we have identified.

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Latest Publications


  • A phase II, multicentre trial of decitabine in higher-risk chronic myelomonocytic leukemia. View In PubMed
  • Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells. View In PubMed
  • Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms. View In PubMed
  • TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis. View In PubMed
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