Skip to Main Content

Aspirin Desensitization

Appointments

Request an appointment online or
call us. 305-243-3564

The term aspirin exacerbated respiratory disease (AERD) – also known as aspirin triad or Samter's Triad – is a complex medical condition that causes asthma, chronic sinusitis, and nasal polyps , as well as a sensitivity or allergy to aspirin products.

If you have AERD, you typically cannot take aspirin or aspirin-containing products since they can cause severe asthma attacks, runny nose, facial/chest/back flushing, and swelling in the throat or skin. Aspirin products also worsen chronic nasal and sinus inflammation (chronic sinusitis), which progresses to blistering of the mucus membranes of the nose and sinuses, known as nasal polyps. The blistering occurs due to the release of chemicals (called cytokines) that produce inflammation. It is the release of these chemicals that your specialist is trying to control with various anti-inflammatory oral or topical medications, or allergy treatment.

AERD-related asthma occurs in less than one percent of patients with AERD, and is more common in women than men. Typically, patients are in their 30s when they notice the onset of this condition. Patients who have severe asthma are more likely to be aspirin sensitive than patients with mild asthma. Similarly, patients with polyps and asthma are more likely to be aspirin sensitive than are patients with only nasal polyps.

AERD-related asthma may run in families and, as with many other causes of chronic sinusitis, is not curable. However, like chronic sinusitis, the asthma may be controllable with appropriate individualized treatments from your sinus specialist working closely with your allergist and pulmonologist. Sometimes this requires endoscopic surgery in addition to aggressive allergy and pulmonary medical management.

Why Choose UHealth?

Highly specialized rhinology doctors. The experts at University of Miami Health are here to help you breathe easier, smell better, and rest better with an accurate diagnosis and leading edge treatments in a compassionate setting. Our fellowship-trained providers specialize in the nasal airway, and our rhinology specialists have completed specialized training in nasal and sinus disorders. They have dedicated their clinical and research careers to caring for nasal and sinus disorders.

Our academic health center provides you with more treatment options. Our ENT specialists are experts in the field of rhinology. As part of an academic health center, we are proud to offer breakthrough treatments not available to other facilities in South Florida. We also offer our patients early access to clinical trials and new medical and procedural treatments. We provide comprehensive care for a wide array of rhinologic conditions, backed by expertise, research, and education.

Questions? We're here to help.

Our appointment specialists are ready to help you find what you need. Contact us today.

Treatments

  • Education

    Treatment of aspirin sensitivity begins with education and establishing a list of drugs that contain aspirin or other NSAIDs, such as ibuprofen.

  • Endoscopic Sinus Surgery

    In patients with chronic sinusitis and nasal polyps, endoscopic sinus surgery can help if their asthma is worsened by their nasal problems. This procedure improves nasal symptoms and allows you to begin a long-term topical medical treatment to control inflammation.

  • Aspirin Desensitization

    In this treatment, you’ll take a regular oral (by mouth) dose of aspirin with the end goal of eliminating the sensitization. This begins at very small doses until you can tolerate 650 mg of aspirin. The typical amount in one tablet of aspirin is 325 mg.

    This is usually done under very close observation by an allergist that is experienced in this treatment, so as to avoid a severe allergic reaction that could be life-threatening. You should not try aspirin desensitization, without specialist supervision.


Tests

  • Physical Examination

    Your ENT doctor will ask you for your thorough medical history and examine you closely in making a diagnosis of aspirin sensitivity. Patients with severe asthma, chronic sinusitis, nasal polyps, and previous problems taking aspirin or non-steroidal anti-inflammatory drugs (NSAIDs such as Advil, Motrin, and Aleve) may have aspirin sensitivity. Your rhinologist may refer you to an allergist for further evaluation and consideration of aspirin desensitization.

  • Provocation Test

    In this test, you are given a small dose of aspirin to determine your reaction. After you’ve taken the aspirin, your allergy specialist will order certain laboratory tests. This must be done in a strictly controlled setting, so that any reaction can be treated appropriately.

Accepted Insurances

Note: Health plans that are currently contracted with UHealth are listed below. However, please check with your insurance provider to verify that UHealth is part of your provider network.

  • Aetna WC
  • Aetna Affiliates/Signature Adm (ASA)
  • Aetna Behavioral Health
  • Aetna Elect Choice (EPO)
  • Aetna Florida Healthy Kids
  • Aetna HMO
  • Aetna Medicaid HMO
  • Aetna Medicare HMO
  • Aetna Medicare PPO
  • Aetna POS
  • Aetna PPO
  • Aetna UM Employee HMO 1
  • Aetna UM Employee HMO 2
  • Aetna UM Employee POS HRA
  • Aetna/Coventry Institutes of Excellence (IOE)
  • Amerigroup Florida Healthy Kids
  • Amerigroup Medicaid HMO
  • Argus Vision
  • AvMed Choice
  • AvMed HMO/POS
  • AvMed MDC and JHS Groups
  • AvMed Medicare HMO
  • AXIS
  • BCBS Blue Options Network Blue PPO
  • BCBS BlueCare HealthOptions HMO
  • BCBS BlueChoice PPC/PPO
  • BCBS Miami Dade Blue PPO Limited Benefits Plan
  • BCBS of Florida (All products except "SELECT" Plans)
  • BCBS of Florida (Commercial plans exclude HIX Select)
  • BCBS Traditional PHS/PPO
  • Beacon Health (ValueOption)
  • Beech Street PPO
  • Broward Health Medical Center
  • CarePlus Medicare HMO
  • Catholic Hospice
  • CCP/CMS Title XIX (Medicaid Enrolled in South Florida)
  • CCP/CMS Title XXI (Non Medicaid Enrolled in South Florida)
  • CCP/MMA (Broward County residents)
  • Charlotte County Sheriffs Office PPO
  • Cigna Affiliates
  • Cigna Behavioral Health
  • Cigna Dental HMO/PPO
  • Cigna EPO
  • Cigna HMO
  • Cigna Life Source (Intracorp is part of Cigna Lifesource)
  • Cigna MDCPS Jackson Sr. High
  • Cigna POS
  • Cigna PPO
  • Cigna Shared Administration
  • Clear Health Alliance SNP Medicaid HMO
  • CompCare (Comprehensive Behavioral Care)
  • Concordia Behavioral Health
  • CorVel WC
  • Coventry First Health WC
  • Coventry Health Care of Florida (HIP) HMO/POS
  • Coventry Health Care of Florida (HIP) PPO
  • Coventry Health Plan of Florida (Foundation) HMO
  • Coventry Health Plan of Florida (Foundation) POS
  • Coventry National PPO
  • Coventry Summit Medicare HMO
  • Coventry Vista Medicare HMO
  • Coventry Vista Medicare HMO
  • Delta Dental PPO
  • DentaQuest (ADI)
  • DIKLA
  • Dimension WC
  • Dimension Plus PPO
  • EHN PPO
  • EQUIAN (Health Systems International)
  • Europe Assistance/Global Corporate Solutions (Care Management Network)
  • eyeQuest
  • FCCI WC
  • Florida Healthcare Plan (Affiliate of BCBSFL)
  • Florida PACE (FPC)
  • Freedom Health Medicaid HMO
  • Freedom Health Medicare HMO
  • Gallagher Bassett WC (MDCPS & FCSRMC)
  • Global Excel Mgt PPO
  • Global Health Claims Services
  • Great West (Cigna) HMO/POS
  • Guardian Life PPO
  • HAA Preferred Partners
  • Health First Health HMO/POS
  • Health First Health Medicare HMO
  • Health First Health PPO
  • Health Net Veterans Choice HMO
  • Heritage Summit Healthcare WC
  • Humana Behavioral Health (LifeSynch)
  • Humana Dental/CompBenefits/OHS
  • Humana EPO
  • Humana HMO
  • Humana HUMx
  • Humana Medicaid HMO
  • Humana Medicare HMO
  • Humana National Transplant
  • Humana PPO
  • Humana Premier
  • iCare Health Solutions
  • Interlink Health Services
  • International Kids Fund (IKF)
  • League Medical Concepts Federal Inmates
  • Life Trac
  • Magellan Behavioral Health
  • Magellan Complete Care SNP Medicaid HMO
  • MDAbroad
  • Medica Medicare HMO
  • Medical Development In't (MDI)-Federal Inmates
  • Medicus
  • Metlife Dental PPO
  • MHNet Behavioral Network (MHNet)
  • Molina
  • Molina Market Place
  • Molina Medicaid HMO
  • Molina Medicare HMO
  • Morgan White International
  • MultiPlan PPO
  • Naphcare (Federal Prisoners)
  • National Healthcare Solutions Inc.
  • Neighborhood HealthPlan HMO/POS
  • Neighborhood HealthPlan PPO
  • North Broward Hospital District PPO
  • Olympus Managed Healthcare
  • Optum
  • Positive Healthcare SNP Medicaid HMO
  • Positive Healthcare SNP Medicare HMO
  • Prestige Health Choice Medicaid HMO
  • Prime Health Services WC
  • Quality Health Management
  • Religious Order of Jehovah's Witnesses PPO
  • Rockport Healthcare Group WC
  • Royal Caribbean Cruises PPO
  • Sanus Health Corporation
  • Simply Healthcare Medicaid HMO
  • Solstice Dental HMO/PPO
  • Start Healthcare Network
  • Sunshine
  • Sunshine AMBETTER
  • Sunshine Healthy Kids HMO
  • Sunshine Medicaid HMO
  • Sunshine Medicare HMO
  • Tricare South Prime HMO
  • Tricare South Standard PPO
  • United Behavioral Health (UBH)
  • UnitedHealthcare Affiliates
  • UnitedHealthcare Healthy Kids HMO
  • UnitedHealthcare HMO/POS
  • UnitedHealthcare Medicaid HMO
  • UnitedHealthcare Medicare Nursing Home Plan
  • UnitedHealthcare PPO
  • University of Miami Athletic Dept PPO
  • VUMI
  • Wellcare/Staywell Healthy Kids HMO
  • Wellcare/Staywell Medicaid HMO
  • Wexford Health State Inmates
  • Worldwide Managed Care