Dr. Sussman aims to: 1) improve strategies to identify families with heritable GI cancer syndromes; 2) improve methods to identify and prevent CRC, including underused modalities like fecal immunochemical testing; 3) identify and clarify the role of molecular markers of GI malignancy; and 4) to develop a repository for patients with GI tract neoplasia related to heritable cancer syndromes, early-onset cancer, or HIV.