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Papanicolau Cancer Research Bldg 234 (M877)
Paolo Serafini, Ph.D.

Paolo Serafini, Ph.D.

  • Research Assistant Professor
  • Microbiology and Immunology
Research InterestPage 1
Dr. Serafini's research interests focus principally on understanding the molecular and cellular pathways that regulate immune tolerance in physiological status as well as in disease. One of the hallmarks of a progressive tumor is activation of abnormal pathological myelopoiesis and recruitment of a heterogeneous population of myeloid cells at different maturation stage characterized by a strong suppressive activity called myeloid derived suppressor cells (MDSC). MDSCs accumulation in the periphery and at the tumor site has been associated with tumor stage and an unfavorable prognosis in many human malignancies and By the release of hematopoietic factors, growing tumors alter the "normal" myelopoiesis and induce the accumulation of MDSC and macrophages that facilitate cancer growth. These cells inhibit the anti-tumor immunity and directly promote tumor growth, angiogenesis, and metastasis. Dr. Serafini's research interests are: To undisclose the molecular mechanisms by which tumor derived factors alter myelopoiesis and to identify molecular target that may restore a myeloid cell differentiation.; Determine the molecular mechanism(s) by which MDSCs restrain tumor immunity to identify new pharmaceutical targets for the generation of new checkpoint inhibitors.; Undisclosed the mechanisms by which MDSCs promote the expansion of antigen specific regulatory T cell. This goal aimed to shift the balance between effector and regulatory T cells with important application in autoimmunity and graft vs host disease.