Trial of Exercise and Lifestyle (TEAL) in Women with Ovarian Cancer (NCT05761561): This is a National Cancer Institute-sponsored study is part of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes consortium. This multi-site randomized, controlled trial is actively recruiting newly diagnosed ovarian cancer survivors at University of Miami and Yale University. The aim of this trial is to explore the effects of an 18-week medical nutrition and exercise therapy program during chemotherapy for ovarian cancer patients to improve chemotherapy completion and quality of life. This study is open and actively recruiting participants at the University of Miami and Yale University.

Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women with Hormone Receptor Positive Advanced Breast Cancer (FastER) (NCT06123988): This National Cancer Institute-sponsored collaboration with Dana-Farber Cancer Center will explore the effect of fasting, exercise, or a combination of fasting and exercise, on fatigue in women with metastatic breast cancer. Additional outcomes will explore biomarkers of inflammation, quality of life, treatment toxicities, physical function, and body composition. This trial is anticipated to open to accrual in early 2024.

NRG-CC012CD: Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment (SYMON)
(NCT Pending): This is an NRG-supported study for patients who are receiving oral chemotherapy treatments for cancer. This study will recruit from 12 cancer clinics across the U.S. and will utilize an automated telephone symptom reporting system to help the patients report their side effects from treatment to their healthcare team. Additionally, patients may receive a psychosocial intervention for elevated symptoms of anxiety and distress. This study is anticipated to open in early 2024.

The Comparative Effectiveness of Lifestyle Interventions for Older Cancer Survivors and their Caregivers (VITALITY) (NCT Pending): This is a PCORI-funded project to compare the effectiveness of a virtually supervised versus remotely monitored diet and exercise intervention on cognitive and physical function in cancers survivors older than 65 years and their caregivers. Survivors of breast, prostate, colorectal, and lung cancers will be eligible, and will participate for one year. This study is anticipated to open in 2024.

Lifestyle Intervention of Food and Exercise for Lymphoma Survivors (LIFE-L) (NCT05839210): This pilot randomized, controlled clinical trial of the Mediterranean diet and supervised, home-based exercise for newly diagnosed lymphoma patients is funded by a gift from the V Foundation for Cancer Research. This trial is actively recruiting new patients at University of Miami and will add to the limited evidence around diet and exercise modifications in this group of cancer survivors.

OnPoint - Precision Oncology Interventions in Nutrition and Training (NCT Pending): This clinical trial and implementation pilot study will test the feasibility and outcomes of a health complexity stratification algorithm to deliver precision diet and exercise support to enrolled participants. Additionally, qualitative exploration of the needs and preference of healthcare providers will be done around the implementation of digital data, such as remote health monitoring device data, into the medical record.

A Secondary Analysis of the LIvES Study (GOG 0225) using Natural Language Processing (NLP) and Machine Learning: This National Cancer Institute-sponsored study is collaboration with the University of Arizona. It is a secondary analysis of recorded telephone health coaching calls, with the goal to using natural language processing and sentiment analysis to develop machine learning models which can predict behavioral outcomes of research participants in lifestyle behavior trials.

For more information on the Crane Lab please visit: https://www.craneresearchlab.org/