Research Focus

The Taylor lab studies the role of recurrent mutations in hematologic malignancies and how to target these with novel therapeutics. Our main focus is on alterations in nuclear export function due to mutations or overexpression of XPO1. We use molecular biology, genomics, proteomics and mouse modeling to determine the mechanisms and potential targetable weaknesses of these genetic alterations. We also study how XPO1 alterations interact with other mutations and the potential role for combination therapy.