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Distinguished Lecture Series

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Sylvester’s Distinguished Guest Lecture Series provides a forum for outstanding clinical and translational researcher guest lecturers to interact and ultimately collaborate with Sylvester faculty. The focus of the series is to bring basic science and clinical researchers together to discuss recent advances in the understanding and treatment of human cancer – a realization of the “bench to bedside” ideal. The audience is typically a mix of clinicians, clinical researchers, basic scientists, and physician scientists.

For UM faculty, staff and students who would like to view the video of these lectures, please click on the ones with (*) next to the name of the presenter.  You can also visit our Distinguished Lecture Series (DLS) channel on Office 365 Stream by searching for DLS (login required).

DLS Speakers 2022 Page 1

Distinguished Lecturer: Raphael E. Pollock, MD, PhD, FACS*
Date of lecture: June 24, 2022
Lecture Title: “Contemporary Perspectives in Retroperitoneal Liposarcoma”

Distinguished Lecturer: Robert J. Coffey, M.D.*
Date of lecture: May 27, 2022
Lecture Title: "Recent Advances in Studies of Extracellular Vesicles and Nanoparticles"

Distinguished Lecturer: David Tuveson, M.D., Ph.D.*
Date of lecture: May 6, 2022
Lecture Title: "Defeating the 7 Deadly Hallmarks of Pancreatic Cancer"

Distinguished Lecturer: Phillipe Armand, M.D., Ph.D.*
Date of lecture: April 1, 2022
Lecture Title: "Checkpoint Failure in Hodgkin Lymphoma"

Distinguished Lecturer: Hans-Guido Wendel, M.D.
Date of lecture: March 18, 2022
Lecture Title: "Biological Vulnerabilities in Lymphoma"

Distinguished Lecturer: George Demetri, M.D.*
Date of lecture: March 11, 2022
Lecture Title: "Lessons to Accelerate Development of Anticancer Therapies from GIST and Other Sarcomas"

Distinguished Lecturer: Nancy Krieger, Ph.D.
Date of lecture: March 4, 2022
Lecture Title: "Structural Racism, Cancer, and the People’s Health: History & Context Matters"

Distinguished Lecturer: Eva Corey, Ph.D.*
Date of lecture: February 11, 2022
Lecture Title: "Prostate Cancer Testosterone: Friend or Foe"

Distinguished Lecturer: John P. Leonard, M.D.*
Date of lecture: January 28, 2022
Lecture Title: "Progress and Challenges in Precision Therapy for Lymphoma"

Distinguished Lecturer: Rong Li, Ph.D.*
Date of lecture: January 21, 2022
Lecture Title: "Breaking Down Cancer Defense Line Against Anti-Tumor Immune Infiltration"

Distinguished Lecturer: Anthony Mato, MD, MSCE*
Date of lecture: January 7, 2022
Lecture Title: "Chronic Lymphocytic Leukemia: The Modern Advancement of Techniques in Care"

DLS Speakers 2021 Page 1

Distinguished Lecturer: Peter Nelson, M.D.*
Date of lecture: December 17, 2021
Lecture Title: "Cancer Therapy Resistance: Anticipating and Targeting New Species Evolving Through Treatment Pressures"

Distinguished Lecturer: Jaroslaw Maciejewski, M.D., Ph.D.*
Date of lecture: October 8, 2021
Lecture Title: "Pathogenetic Implications of TET2 Deficiency for Synthetic Lethal Strategies"

Distinguished Lecturer: Dmitry Gabrilovich, M.D., Ph.D.*
Date of lecture: September 17, 2021
Lecture Title: "Myeloid-derived Suppressor Cells in Regulation of Immune Responses and Tumor Progression"

Distinguished Lecturer: Jen Jen Yeh, M.D.*
Date of lecture: June 18, 2021
Lecture Title: "Pancreatic Cancer Subtyping for the Clinic"

Distinguished Lecturer: Felix Feng, M.D.*
Date of lecture: June 11, 2021
Lecture Title: "Identifying Molecular Drivers of Metastatic Prostate Cancer Through Clinical and Functional Genomic Approaches"

Distinguished Lecturer: Frank McCormick, PhD, FRS, DSc (Hon)*
Date of lecture: May 14, 2021
Lecture Title: "RAS Proteins in Human Disease"

Distinguished Lecturer: Akiko Shimamura, M.D., Ph.D.*
Date of lecture: April 16, 2021
Lecture Title: "Molecular Mechanisms of Clonal Evolution in Bone Marrow Failure"

Distinguished Lecturer: John Carpten, Ph.D.
Date of lecture: March 26, 2021
Lecture Title: “The Impact of Population and Tumor Heterogeneity in Cancer Genome Science”

Distinguished Lecturer: Sarki Abdulkadir, M.D., Ph.D.*
Date of lecture: March 12, 2021
Lecture Title: "Small Molecule MYC Inhibitors for Cancer Therapy"

Distinguished Lecturer: Rugang Zhang, Ph.D.*
Date of lecture: February 26, 2021
Lecture Title: "Epigenetic Approaches to Epithelial Ovarian Cancer"

Distinguished Lecturer: Aimee Edinger, V.M.D./Ph.D.
Date of lecture: February 19, 2021
Lecture Title: “Leveraging Sphingolipids to Modulate Metabolism in Cancer and Other Diseases”

Distinguished Lecturer: David Virshup, M.D.*
Date of lecture: February 5, 2021
Lecture Title: "Upstream Regulation of Wnt Signaling: Biology and Therapy"

Distinguished Lecturer: Andrea Califano, Dr.*
Date of lecture: January 22, 2021
Lecture Title: "Elucidating and Targeting Mechanisms of Single Cell State Maintenance"

Distinguished Lecturer: Kunle Odunsi, M.D., Ph.D.
Date of lecture: January 15, 2021
Lecture Title: "New Insights on Overcoming Innate and Adaptive Immune Resistance in Ovarian Cancer"

DLS Speakers 2020 Page 1

Distinguished Lecturer: Sarat Chandarlapaty, M.D., Ph.D.*
Date of lecture: November 20, 2020
Lecture Title: "Challenges and Opportunities in Targeted Therapy of Breast Cancer"

Distinguished Lecturer: Aaron Ring, M.D., Ph.D.*
Date of lecture: November 13, 2020
Lecture Title: "Engineered Cytokines in Cancer Immunotherapy"

Distinguished Lecturer: Wendy Demark-Wahnefried, PhD, RD*
Date of lecture: November 6, 2020
Lecture Title: "Creating Scalable Behavioral Interventions to Improve the Health of Cancer Survivors"

Distinguished Lecturer: Deborah Mayer, PhD, RN, AOCN, FAAN*
Date of lecture: September 25, 2020
Lecture Title: "Cancer Survivorship: Unmet Needs and Research Priorities"

Distinguished Lecturer: Yibin Kang, Ph.D.*
Date of lecture: February 7, 2020
Lecture Title: “Identification and Therapeutic Targeting of a Breast Cancer Metastasis Gene"

Distinguished Lecturer: Paul Jacobsen, Ph.D.*
Date of lecture: January 31, 2020
Lecture Title: “Improving Cancer Care and Outcomes: The Role of Healthcare Delivery Research"

Distinguished Lecturer: Karlene Cimprich, Ph.D.*
Date of lecture: January 24, 2020
Lecture Title: “The Causes and Consequences of Replication Stress"

Distinguished Lecturer: J. Silvio Gutkind, Ph.D.*
Date of lecture: January 17, 2020
Lecture Title: “Targeting the mTOR and Hippo Signaling Networks in Cancer: Opportunities for Multimodal Precision Immunotherapies"

Distinguished Lecturer: Cristina Antonescu, M.D.*
Date of lecture: January 10, 2020
Lecture Title: “Recent Advances in the Molecular Classification of Mesenchymal Tumors"

DLS Speakers 2019 Page 1

Distinguished Lecturer: Scarlett Lin Gomez, PhD, MPH*
Date of lecture: December 13, 2019
Lecture Title: “Building Infrastructures to Address Multilevel Social Determinants of Health Disparities"

Distinguished Lecturer: Everett Vokes, MD*
Date of lecture: November 22, 2019
Lecture Title: “De-escalation of Treatment Intensity in Head and Neck Cancer

Distinguished Lecturer: Marianne Sadar, PhD*
Date of lecture: November 15, 2019
Lecture Title: “Drugging the Undruggable: Developing a New Therapy for Castration Resistant Prostate Cancer

Distinguished Lecturer: Daniel Durocher, PhD*
Date of lecture: November 8, 2019
Lecture Title: “Charting the Human DNA Damage Response

Distinguished Lecturer: Stanley R. Hamilton, MD, FCAP, AGAF*
Date of lecture: November 1, 2019
Lecture Title: “Precision Oncology. Really?

Distinguished Lecturer: Ie-Ming Shih, MD, PhD*
Date of lecture: September 20, 2019
Lecture Title: “The Origin of Ovarian Cancer Precursor Species"

Distinguished Lecturer: Alex Kentsis, MD, PhD*
Date of lecture: September 13, 2019
Lecture Title: “Jumping Genes and Proteomics for New Cancer Therapies"

Distinguished Lecturer: Paolo Sassone-Corsi, PhD*
Date of lecture: May 10, 2019
Lecture Title: “The Epigenetics Language of Circadian Metabolism"

Distinguished Lecturer: Cathrine Hoyo, PhD*
Date of lecture: April 5, 2019
Lecture Title: “Trace Metals, Liver Cancer Susceptibility and Epigenomics"

Distinguished Lecturer: Mary J.C. Hendrix, PhD*
Date of lecture: March 15, 2019
Lecture Title: “Targeting the Stem Cell Phenotype of Aggressive Cancer Cells

Distinguished Lecturer: J. Michael Oakes, PhD*
Date of lecture: February 22, 2019
Lecture Title: “Community-Engaged Research Leadership: The RWJF IRL Program

Distinguished Lecturer: Eirini Papapetrou, MD, PhD*
Date of lecture: February 1, 2019
Lecture Title: “Modeling Leukemia Stem Cells and Clonal Evolution with Human Induced Pluripotent Stem Cells

DLS Speakers 2018 Page 1
Distinguished Lecturer: Iman Osman, MD*
Date of lecture: December 7, 2018
Lecture Title: “Moving Forward in the New Era of Effective Melanoma Systemic Therapy

Distinguished Lecturer: Jonathan D. Licht, MD*
Date of lecture: November 2, 2018
Lecture Title: “Disorders of Histone Methylation in Hematological Malignancy

Distinguished Lecturer: Marc Ladanyi, MD*
Date of lecture: October 19, 2018
Lecture Title: “Clinical Tumor: Normal Genomic Profiling to Guide Patient Selection for Targeted and Immune Therapies and Screen for Germline Cancer Predisposition and Clonal Hematopoiesis

Distinguished Lecturer: Maciej Wiznerowicz, MD, PhD*
Date of lecture: October 5, 2018
Lecture Title: “Cancer Stemness as Hallmark of Oncogenic Progression

Distinguished Lecturer: Maha Hussain, MD*
Date of lecture: April 27, 2018
Lecture Title: “Translating Biology into Therapeutics in Prostate Cancer: Progress & Ongoing Discoveries

Distinguished Lecturer: Tyler Curiel, MD*
Date of lecture: April 20, 2018
Lecture Title: "Novel Tumor Intrinsic PD-L1/PD-1 Signals: Revising the Immune Checkpoint Paradigm"

Distinguished Lecturer: David DeNardo, PhD
Date of lecture: March 30, 2018
Lecture Title: “Targeting the pancreatic tumor microenvironment to unlock response to immunotherapy

Distinguished Lecturer: Susann Brady-Kalnay, PhD*
Date of lecture: March 23, 2018
Lecture Title: “Detection of tumors by PTPmu molecular imaging agents

Distinguished Lecturer: Louis M. Staudt, MD, PhD*
Date of lecture: March 9, 2018
Lecture Title: “Precision Lymphoma Therapies Guided by Genomics

Distinguished Lecturer: Jennifer Grandis, MD*
Date of lecture: March 2, 2018
Lecture Title: “Head and Neck Cancer Precision Medicine

Distinguished Lecturer: James Brugarolas, MD, PhD*
Date of lecture: February 16, 2018
Lecture Title: “Molecular Genetics, Biology and Translation

Distinguished Lecturer: Samuel Achilefu, PhD*
Date of lecture: February 9, 2018
Lecture Title: “High Throughput Surgery Using Cancer Goggles

Distinguished Lecturer: John E. Dick, PhD*
Date of lecture: February 1, 2018
Lecture Title: “Stem Cells in Leukemia Matter from the Beginning to the End

Distinguished Lecturer: Omar Abdel-Wahab, MD*
Date of lecture: January 26, 2018
Lecture Title: "Understanding and Targeting Spliceosomal Gene Mutations in Cancer"

Distinguished Lecturer: Iannis Aifantis, PhD*
Date of lecture: January 19, 2018
Lecture Title: “Transcriptional and Post-Translational Regulation of Stress Response in Cancer

Distinguished Lecturer: Marian L. Neuhouser, PhD, RD*
Date of lecture: January 12, 2018
Lecture Title: “Obesity and Postmenopausal Breast Cancer: Biological Mechanisms and Clinical Applications

Distinguished Lecturer: Scott Woodman, MD, PhD*
Date of lecture: January 5, 2018
Lecture Title: “A Comprehensive and Integrated Analysis of Uveal Melanoma
DLS Speakers 2017 Page 1
Distinguished Lecturer: Oliver McDonald MD, PhD*
Date of lecture: December 15, 2017
Lecture Title: “Metabolic-Epigenomic Reprogramming During Pancreatic Cancer Progression"

Distinguished Lecturer: Danny Welch, PhD*
Date of lecture: October 27, 2017
Lecture Title: “Breast Cancer Metastasis: Role of Host and Tumor Cell Mitochondrial Genetics

Distinguished Lecturer: Xosé R. Bustelo, PhD
Date of lecture: June 16, 2017
Lecture Title: “Bivalent Roles of Vav Oncoproteins in Cancer: Genetic Evidence and Potential Translation to Human Settings"

Distinguished Lecturer: Henry Rodriguez, PhD
Date of lecture: May 26, 2017
Lecture Title: “Omics Convergence in Cancer Research - Advances in Biology and Precision Medicine

Distinguished Lecturer: Massimo Loda, MD*
Date of lecture: April 28, 2017
Lecture Title: “Metabolic Dependencies in Prostate cancer: Regulation and Targeting of Lipogenesis

Distinguished Lecturer: Dr. Stephen J Weiss
Date of lecture: April 25, 2017
Lecture Title: “Breast Cancer Initiation & Progression: Interplay of Transcription Factor and Proteolytic Effector Networks

Distinguished Lecturer: Ajay Goel, PhD
Date of lecture: April 18, 2017
Lecture Title: “Noncoding RNAs as Liquid Biopsy Biomarkers in Gastrointestinal Cancer

Distinguished Lecturer: Yoshiaki Ito, MD, PhD*
Date of lecture: March 24, 2017
Lecture Title: “Emerging Roles of RUNX Transcription Factors

Distinguished Lecturer: Daniel Starczynowski, PhD*
Date of lecture: March 17, 2017
Lecture Title: “Modeling and Targeting Innate Immune Signaling Pathways in Hematologic Malignancies

Distinguished Lecturer: Ross Levine, MD*
Date of lecture: March 3, 2017
Lecture Title: “Role of mutations in epigenetic regulators in myeloid leukemogenesis and targeted therapy

Distinguished Lecturer: Ulrich Steidl, MD, PhD*
Date of lecture: February 17, 2017
Lecture Title: “Mechanisms of Formation and Progression of Pre-Cancerous Stem Cells

Distinguished Lecturer: Dean Felsher, MD, PhD*
Date of lecture: February 10, 2017
Lecture Title: “Oncogene Addiction and the Immune Response

Distinguished Lecturer: Lee Helman, MD*
Date of lecture: February 3, 2017
Lecture Title: “Identification of new targets for the treatment of Ewing’s Sarcoma

Distinguished Lecturer: Craig Moskowitz, MD*
Date of lecture: January 20, 2017
Lecture Title: “Relapsed/Refractory Hodgkin Lymphoma 2017

DLS Speakers 2016 Page 1
Distinguished Lecturer: Lee Ellis, MD, FACS, FASCO*
Date of lecture: November 18, 2016
Lecture Title: “The Erosion of Research Integrity: The Need For a Culture Change

Distinguished Lecturer: Mario Capecchi, PhD*
Date of lecture: November 11, 2016
Lecture Title: “Gene Targeting into the 21st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders

Distinguished Lecturer: Dennis Weisenburger, MD*
Date of lecture: October 14, 2016
Lecture Title: “New Insight into Peripheral T-Cell Lymphoma

Distinguished Lecturer: Rick Kittles, PhD*
Date of lecture: September 23, 2016
Lecture Title: “The Use of Genetic Ancestry to Understand Cancer Disparities