• Shembade Lab

Chronic inflammation mediated by a transcription factor, NF- κB, in HTLV-1, EBV, and KSHV-infected cells plays a critical role in the development of oncogenic virus-associated malignancies. One of the main mechanisms of persistent NF- κB activation in oncogenic virus-infected cells is dysregulation of the function of host factors by viral oncogenes. However, the cellular host factors required for persistent NF- κB activation in oncogenic virus-infected cells remains largely unknown. Thus, their focus determines the host factors that are involved in chronic activation of NF- κB and inflammation in HTLV-1, EBV, and KSHV-infected cells.