Research Focus

The regulation of the immune response relies on the cell type-specific, spatiotemporal controlled, integrated regulation of multiple genes often expressed by other tissues. Hence, classical methods such as the generation of knock-out mice or the administration of agonists and antagonists are inadequate to reveal the delicate mechanisms that regulate the immune response in vivo and are difficult to be translated into safe new treatments for patients with cancer and autoimmune diseases.

By conjugating the advancement in nanotechnology and the power of RNA therapeutics, we can modulate gene expression specifically into the desired cell type at the desired time.